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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Plumbagin, Cisplatin
Phytochemical Name Plumbagin (PubChem CID: 10205 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 301
Ref_1
Pair Name Plumbagin, Cisplatin
Disease Info [ICD-11: 2B62.0] Tongue squamous cell carcinoma Investigative
Biological Phenomena Induction-->ROS accumulation
Gene Regulation Down-regulation Expression AKT1 hsa207
Up-regulation Activity MAPK8 hsa5599
Down-regulation Expression MTOR hsa2475
Up-regulation Expression ROS1 hsa6098
In Vitro Model CAL-27 Tongue adenosquamous carcinoma Homo sapiens (Human) CVCL_1107
In Vivo Model Each mouse was injected with 0.15 mL of cell suspension containing 1×10⁶ CAL27/CDDP cells into the right flanks.
Result PLB combined with cisplatin is a potential therapeutic strategy against therapy TSCC cisplatin resistance.
03. Reference
No. Title Href
1 Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma. Oxid Med Cell Longev. 2020 Mar 25;2020:5649174. doi: 10.1155/2020/5649174. Click
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