| Pair Name | Plumbagin, Cisplatin | ||
| Phytochemical Name | Plumbagin (PubChem CID: 10205 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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MOL
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| Structure of Anticancer Drug |
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| Pair Name | Plumbagin, Cisplatin | |||
| Disease Info | [ICD-11: 2B62.0] | Tongue squamous cell carcinoma | Investigative | |
| Biological Phenomena | Induction-->ROS accumulation | |||
| Gene Regulation | Up-regulation | Expression | ROS1 | hsa6098 |
| Up-regulation | Activity | MAPK8 | hsa5599 | |
| Down-regulation | Expression | AKT1 | hsa207 | |
| Down-regulation | Expression | MTOR | hsa2475 | |
| In Vitro Model | CAL-27 | Tongue adenosquamous carcinoma | Homo sapiens (Human) | CVCL_1107 |
| In Vivo Model | Each mouse was injected with 0.15 mL of cell suspension containing 1×10⁶ CAL27/CDDP cells into the right flanks. | |||
| Result | PLB combined with cisplatin is a potential therapeutic strategy against therapy TSCC cisplatin resistance. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma. Oxid Med Cell Longev. 2020 Mar 25;2020:5649174. doi: 10.1155/2020/5649174. | Click |
